Failed IVF Patients

Please remember that pregnancy rates with IVF/ICSI are in the range of 40-50% per cycle. After making provisions for early or late miscarriages, pregnancy losses, ectopic pregnancies, the net live birth rate is in the range of 37% per cycle. This means that 63% of treatments would fail.

Our chief staff is constantly updated on the lines of ESHRE and ASRM recommendations to ensure that the patients get only the best of medical care and technology

Only recently, the clinic switched to a “freeze-all” policy after a meticulous application of embryo vitrification techniques and research on endometrial receptivity. It is not proven that a lot of patients fail IVF with fresh embryo transfer because the endometrium was not in a receptive state during the stimulation cycle. With better vitirication techniques there is no damage to frozen embryos. Focus has now shifted to optimizing the endometrial receptivity prior to embryo transfer and this can only be achieved in frozen embryo transfer cycles. Take home baby rates improved by 10% (45% as against 35% in 2013) with adoption of this newer approach. With the “freeze all” strategy, we are able to achieve success in many patients who had failed previously owing to age, abnormal estradiol and progesterone levels during the stimulation cycle, endometriosis, polycystic ovaries, ovarian hyperstimulation, poor response, thin endometrium and unexplained implantation failure. We are excited and looking forward to our yearly audit in the first week of January 2017 in anticipation of our statistics reaching 50% ongoing pregnancy rates with this exciting new approach (Freeze all).

Other common causes of failure are:
  • Suboptimal sperm quality (especially ICSI patients with sperm problems)
  • Suboptimal egg quality (patients > 35 years of age or low AMH levels, Polycystic ovaries and endometriosis)
  • Thin lining of the uterus (endometrium) or insufficient blood supply in the uterus
  • Hormonal imbalances created by the injections given to produce good eggs which might put the uterus out of phase for receiving the embryo
  • Improper response of the ovaries to the ovarian stimulation protocol used (short antagonist or long agonist)
  • Most importantly, the CHANCE (only 37% at best) per cycle. This implies that even if all goes well, failure might be unexplained and implies the necessity for more cycles or attempts
Measures might be suggested
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